Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development
نویسندگان
چکیده
منابع مشابه
CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L.
Chromatin remodeling complexes play critical roles in development. Here we describe a transcription factor, CECR2, which is involved in neurulation and chromatin remodeling. CECR2 shows complex alternative splicing, but all variants contain DDT and bromodomain motifs. A mutant mouse line was generated from an embryonic stem cell line containing a genetrap within Cecr2. Reporter gene expression ...
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Inner ear neurogenesis is positively regulated by the pro-neural bHLH transcription factors Ngn1 and NeuroD, but the factors that act upstream of this regulation are not well understood. Recent evidence in mouse and Drosophila suggests that neural development depends on proper chromatin remodeling, both for maintenance of neural stem cells and for proper neuronal differentiation. Here, we show ...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2011
ISSN: 1058-8388
DOI: 10.1002/dvdy.22547